ABSTRACT
Objective To observe the clinical efficacy of fasudil combined with fibrinogenase for injection on sudden sensorineural hearing loss of old people. Methods Ninety old patients with sudden sensorineural hearing loss were randomly divided into fasudil group, fibrinogenase group and combined group (n=30 in each group).After the treatment, improvement of deafness and tinnitus were compared among the three groups. Hemorrheology, coagulation function, blood routine examination, liver and kidney function profile, and blood lipid were compared before and after the treatment. Results The total effective rate of deafness was significantly higher in the combined group ( 93. 3%) than in the fasudil group ( 90. 0%) and the fibrinogenase group (86.7%) (both P<0.05).The total effective rate of tinnitus was significantly higher in the combined group (93.3%) than in the fasudil group (83.3%) and the fibrinogenase group (80.0%) (both P<0.05).After the treatment, blood viscosity and coagulation function were significantly improved in the three groups (all P<0.05).As compared with the fasudil group and the fibrinogenase group, blood viscosity was significantly improved in the combined group (both P<0.05). Conclusion Fasudil combined with the fibrinogenase for injection for sudden sensorineural hearing loss of the old people has preferable curative efficacy, and can effectively improve clinical symptom, blood viscosity and coagulation function of sudden sensorineural hearing loss.
ABSTRACT
@#Parkinson's disease (PD) is one of the most prevalent neurodegenerative movement disorder in human being, characterized by progressive degeneration and lost of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc),causing low level of DA in the nigrostriatal pathway, eventually leading to motor dysfunctions including tremor, rigidity, bradykinesia,and postural instability.The pathology of PD is complex and the etiology remains poorly understood. In recent years,inflammation has been suggested to be involved in the occurrence and development of PD, by activation of microglia and overexpression of the inflammatory factors. And anti-inflammatory drugs has been developed to delay or prevent the progressive course of PD, becoming a new hotspot in treatment of PD. In this review, the latest progresses on the inflammatory mechanisms and anti-inflammatory treatments of PD was introduced.
ABSTRACT
Objective To observe the effect of buflomedil on patients with vascular dementia. Methods Sixty - four patients with vascular dementia were randomly divided into two groups.The buflomedil group of 32 patients was treated with buflomedil 150-200 mg,once a day for 20 days. The control group of 32 patients was treated with citicolinum 750 mg, once a day for 20 days. Then their MMSE, ADL, HDS and WMS were evaluated and the hemorheologic indexes were measured in both groups before and after treatment, respectively. Results In buflomedil group the scores of MMSE, ADL,HDS and WMS were (22.43?3.03) score,(24.43?8.72) score,(23.41?2.81) score,(70.34 ?18.45) score as that were(20. 58?3. 81) score, (29. 23?14. 36) score, (20. 34?6. 24) score, (60.15?22.49) score in control group.There was significant difference between the two groups(P